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Multi-domain proteins (alpha and beta)

- Serpins
- FdhE-like
- FlhC-like
- Replication terminator protein (Tus)
- VPA0735-like
- 2-methylcitrate dehydratase PrpD
- Antivirulence factor
- Api92-like
- PH0156-like
- YacF-like
- Virulence-associated V antigen
- Heme-dependent catalases
- Allene oxide synthase
- Medium chain acyl-CoA dehydrogenase, NM (N-terminal and middle) domains
- acyl-CoA oxidase N-terminal domains
- Inositol monophosphatase/fructose-1,6-bisphosphatase-like
- GlpX-like bacterial fructose-1,6-bisphosphatase
- DNA polymerase I
- Lesion bypass DNA polymerase (Y-family), catalytic domain
- Reverse transcriptase
- T7 RNA polymerase
- RNA-dependent RNA-polymerase
- dsRNA phage RNA-dependent RNA-polymerase
- RNA-polymerase beta
- RNA-polymerase beta-prime
- Poxvirus poly(A) polymerase catalytic subunit-like
- Adenylylcyclase toxin (the edema factor)
- Prokaryotic type I DNA topoisomerase
- Type II DNA topoisomerase
- DNA topoisomerase IV, alpha subunit
- DNA primase DnaG catalytic core
- Primase fragment of primase-helicase protein
- Recombination protein RecR
- Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment
- D-aminoacid aminotransferase-like PLP-dependent enzymes
- Nickel-iron hydrogenase, large subunit
- Nqo4-like
- Nickel-iron hydrogenase, small subunit
- Nq06-like
- Dehydroquinate synthase, DHQS
- Iron-containing alcohol dehydrogenase
- Siroheme synthase middle domains-like
- Acetyl-CoA synthetase-like
- Ribosomal protein L1
- Release factor
- YaeB-like
- MalF N-terminal region-like
- YebC-like
- Cullin homology domain
- Sec1/munc18-like (SM) proteins
- Carbon monoxide dehydrogenase
- Hybrid cluster protein (prismane protein)
- Acetyl-CoA synthase
- Capz alpha-1 subunit
- Capz beta-1 subunit
- beta-Lactamase/D-ala carboxypeptidase
- Glutaminase
- Dac-like
- Upper collar protein gp10 (connector protein)
- AF1531-like
- Phase 1 flagellin
- 39 kda initiator binding protein, IBP39, C-terminal domains
- AF1104-like
- Cas DxTHG
- Urocanase
- NAD kinase-like
- Diacylglycerol kinase-like
- QueA-like
- CbiD-like
- Rap/Ran-GAP
- Vacuolar ATP synthase subunit C
- Thermophilic metalloprotease (M29)
- ImpE-like
- CV3147-like
- HemS/ChuS-like
- ChuX-like
- HI0933 insert domain-like
- NSP3 homodimer
- DP dimerization segment
- E2F dimerization segment
- Membrane penetration protein mu1
- Flu NP-like
- Glycoprotein B-like
- Spike glycoprotein-like
- Orbivirus core
- Phytoreovirus core
- L-A virus major coat protein
- Major capsid protein VP5
- Viral ssDNA binding protein